Profile

About Me:

Telling people about me and where I’m from is a complicated question… My Mum is Italian and my Dad is Chinese, but I was born in the USA and I lived in London since I was 4 years old. Growing up I always enjoyed making things and solving problems, whether it be a puzzle or how to build a castle out of lego. I was also that kid who always asked, “…but why?” and I’m still the same today. I love finding out how and why things work as well as wanting to help people. This combination lead me to study bioengineering to develop new technology to repair damaged or diseased tissues in the human body.

When you enjoy what you do, it can be difficult to separate your work-related interests from extra-curricular hobbies – which I think is a positive thing. So outside work I am involved with Christians in Science and Women in Engineering. I’m a STEM ambassador with STEMNET too. As I mentioned before, I love people too so I love spending time with friends and family, eating delicious food, going for a walk in The Peaks or travelling to a new place to explore. When I can, I love reading (ideally on the beach!), swimming and going for walks.

About My Work:

I decided to do a MSc to give myself the opportunity to study something I love and wanted to know more about (I was doing a PhD, but sadly had to change paths because I was diagnosed with a chronic illness). My MSc was in Tissue Engineering and Regenerative Medicine which is a field that involves a range of technologies that seek to help the body repair and restore itself. Millions of people suffer from damaged bone from an accident or disease. My research was looking into a new technology called cell sheet technology, which I’m developing to use to help repair and regenerate damaged bone. Cells are cultured to form sheets that can be detached and stacked together to make a 3D tissue (Figure 1 and 2), a bit like stacking layers of a cake together. Then this can be combined with a material called a scaffold, a bit like scaffolding on a building it helps to support the cells when you put it in the area of damaged bone. Ideally this scaffold will degrade in the body at the rate that new bone is formed, and the cell sheets should help speed up this process.

Figure 1: Advantages of cell sheet technology compared to normal cell culture methods. This includes avoiding damaging the cells and the extracellular matrix (ECM), which are key components that can be kept to provide an effective clinical treatment. The ECM is secreted by cells to provide structural and biochemical support to the surrounding cells, which is the main component of bone.

Figure 2: Stacking layers of cell sheets to make a multi-layered cell sheet that forms a 3D tissue.

I didn’t have a very typical day. The great thing about being a researcher is that you can manage your own time, so my timetable was flexible. Although, it does mean that you have to motivate yourself to get work done and figure out how to fix problems on your own.

I worked in a lab which is in St. James Hospital, Leeds. I would do experiments most days, although the work is varied since my research involves different subjects (Biology, Chemistry, Physics, Maths and Engineering) so I didn’t get bored. A large part of my work involved culturing cells (Figure 3), then using microscopes to look at them and analyse them (Figure 4). I also use special tests and machines to analysing things further.

Sometimes I went into surgery to watch operations and collect cell samples that I later took to the lab to do experiments on (Figure 5 and 6 see the bottom of my profile). A few times a year I also got to go to conferences and do placements at other labs or in industry, which are sometimes abroad. By far my favourite placement, I spent 3 months in Japan, 2 months of it was working in a lab in Tokyo.

Figure 3: Picture of a cell culture hood which is a clean place where you can grow cells and move them between dishes.

Figure 4: A microscope image of cells tagged with fluorescent markers. Blue: cell nuclei; Green and Red: extracellular matrix (ECM). The ECM is secreted by cells to provide structural and biochemical support to the surrounding cells, which is the main component of bone.